In the case of diabetes, dry mouth can occur due to a few different reasons:
- High blood sugar levels: When blood glucose levels are consistently high in individuals with diabetes, it can lead to increased urination (polyuria) and subsequent dehydration. Dehydration can contribute to dry mouth.
- Neuropathy: Diabetes can cause nerve damage, including damage to the nerves that stimulate saliva production. When these nerves are affected, it can result in decreased saliva production and dry mouth.
- Medications: Many people with diabetes take medications to manage their condition. Some of these medications, such as certain antihyperglycemic drugs, may list dry mouth as a side effect.
Diabetes medications that can cause dry mouth
Several medications used to manage diabetes can potentially cause dry mouth as a side effect. These may include:
- Antihyperglycemic medications: Certain classes of antihyperglycemic drugs, such as dipeptidyl peptidase-4 (DPP-4) inhibitors, can sometimes lead to dry mouth. Examples of DPP-4 inhibitors include sitagliptin, saxagliptin, linagliptin, and alogliptin.
- Sodium-glucose co-transporter-2 (SGLT2) inhibitors: While SGLT2 inhibitors are generally well-tolerated, they can occasionally cause dry mouth as a side effect. Common SGLT2 inhibitors include canagliflozin, dapagliflozin, and empagliflozin.
- Tricyclic antidepressants (TCAs): TCAs are occasionally used to manage neuropathic pain associated with diabetes. However, these medications can also cause dry mouth as a side effect. Examples of TCAs include amitriptyline, nortriptyline, and desipramine.
Never stop or change a medication without talking to your doctor or pharmacist. Aquoral can relieve the symptoms of dry mouth while you continue your treatment.
This page is general information and does not replace advice from your health professional. Content adapted for Canada; pending review.